基本信息

姓    名：何一燕

性    别：

出生年月： 

籍    贯：

职    称：教授、硕导

电子邮箱：yiyanhe@njtech.edu.cn

办公地点：润德楼(材料学科楼)B503、丁家桥科创大楼A605

学缘与工作经历

2023-至今，beat365官方网站，教授，硕导

2018-2019，新加坡科技研究局生物工程与纳米技术研究院，国家公派访问学者

2017-2022，beat365官方网站，副教授，硕导

2016-2018，四川大学国家生物医学材料工程技术研究中心，博士后

2014-2017，四川大学国家生物医学材料工程技术研究中心，讲师

2009-2014，四川大学国家生物医学材料工程技术研究中心，博士

2005-2009，四川大学化学学院，本科

教学与科研简介

承担《计算机在高分子中的应用》、《高分子材料》、《毕业实习》、《认识实习》、《专业导学》等本科生课程和《生物材料》、《信息检索》等研究生课程的教学工作。曾获校青年教师授课竞赛一等奖、校微课教学比赛特等奖等。指导本科生大创省级/校级项目10余项，本科毕业论文50余名，获校级优秀毕业论文多篇，多次获评优秀指导教师。指导研究生20余名。

主要从事纳米智能生物材料和自主性高分子水凝胶材料在重大疾病治疗和软组织修复，以及硅水凝胶材料等的相关基础研究与应用开发工作。先后主持国家自然科学基金面上项目、青年基金、国家重点研发计划项目子课题、教育部产学合作协同育人项目、中国博士后科学基金面上一等资助等项目。在Advanced Materials、Biomaterials、Advanced Healthcare Materials、ACS Applied Materials & Interfaces和Carbohydrate Polymers等高水平期刊上发表论文50余篇，授权美国发明专利1件、欧洲发明专利1件、中国发明专利10余件。多次参与组织中国材料大会的生物医用材料分会和新材料产业发展大会的生物医用材料分论坛。

高水平代表性论文

[1]  Fernando López Lasaosa, Yin Zhou, Jiliang Song, Yiyan He*, Yuwen Cui*, Rosa María Bolea Bailo, Zhongwei Gu*. Nature-Inspired Scarless Healing: Guiding Biomaterials Design for Advanced Therapies. Tissue Engineering -Part B: Reviews 2024, DOI: 10.1089/ten.TEB.2023.0224.

[2]  Jingjing Wei, Yin Zhou, Yiyan He*, Wentao Zhao, Zhiqiang Luo, Jian Yang*, Hongli Mao*, Zhongwei Gu. Customizing biomimetic surface attributes of dendritic lipopeptide nanoplatforms for extended circulation. Nanomedicine: Nanotechnology Biology and Medicine, 2024, 56, 102726. 

[3]  Ming Yuan, Shuangshuang Xu, Yin Zhou, Yi Chen, Jiliang Song, Shengnan Ma, Yiyan He*, Hongli Mao, Deling Kong, Zhongwei Gu. A facile bioorthogonal chemistry-based reversible to irreversible strategy to surmount the dilemma between injectability and stability of hyaluronic acid hydrogels. Carbohydrate Polymers 2023, 317, 121103.

[4]  Jiajun Qin, Ming Li, Ming Yuan, Xinglei Shi, Jiliang Song, Yiyan He*, Hongli Mao, Deling Kong, and Zhongwei Gu*. Gallium(III)-Mediated Dual-Cross-Linked Alginate Hydrogels with Antibacterial Properties for Promoting Infected Wound Healing. ACS Applied Materials & Interfaces 2022, 14(19): 22426-22442.

[5]  Ming Li, Xinglei Shi, Bo Yang, Jiajun Qin, Xiaobao Han, Wanjia Peng, Yiyan He*, Hongli Mao, Deling Kong, Zhongwei Gu*. Single-component hyaluronic acid hydrogel adhesive based on phenylboronic ester bonds for hemostasis and wound closure. Carbohydrate Polymers 2022, 296, 119953.

[6]  Yuhang Jiang, Wentao Zhao, Shuangshuang Xu, Jingjing Wei, Fernando López Lasaosa, Yiyan He*, Hongli Mao, Rosa María Bolea Bailo, Deling Kong, Zhongwei Gu*. Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization. Biomaterials 2022, 280, 121323.

[7]  Jie Zhou, Shengnan Ma, Yuxin Zhang, Yiyan He*, Hongli Mao, Jun Yang, Hu Zhang, Kui Luo, Qiyong Gong, Zhongwei Gu*. Bacterium-mimicking sequentially targeted therapeutic nanocomplexes based on O-carboxymethyl chitosan and their cooperative therapy by dual-modality light manipulation. Carbohydrate Polymers 2021, 264, 118030.

[8]  Jie Zhou, Shengnan Ma, Yuxin Zhang, Yiyan He*, Jun Yang, Hu Zhang, Kui Luo, Zhongwei Gu*. Tunable membrane-penetrating bioreductive nanogels based on guanidinylated dendrimers for programmable gene delivery. Applied Materials Today 2020, 20, 100646.

[9]  Jie Zhou, Shengnan Ma, Yuxin Zhang, Yiyan He*, Jun Yang, Hu Zhang, Kui Luo, Zhongwei Gu*. Virus-inspired mimics: dual-ph-responsive modular nanoplatforms for programmable gene delivery without dna damage with the assistance of light. ACS Applied Materials & Interfaces 2020,12: 22519−22533.

[10]  Bo Yang, Jiliang Song, Yuhang Jiang, Ming Li, Jingjing Wei, Jiajun Qin, Wanjia Peng, Fernando López Lasaosa, Yiyan He*, Hongli Mao, Jun Yang, and Zhongwei Gu*. An injectable adhesive self-healing multi-cross-linked double-network hydrogel facilitates full-thickness skin wound healing. ACS Applied Materials & Interfaces 2020, 12, 52: 57782–57797.

[11]  Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang*, Yiyan He*, Chuntao Tian and Guijun Qin* Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs. RSC Advances 2023,13, 11269-11277.

[12]  Shengnan Ma, Jie Zhou, Yuxin Zhang, Bo Yang, Yiyan He*, Chen Tian, Xianghui Xu, Zhongwei Gu*. An oxygen self-sufficient fluorinated nanoplatform for relieved tumor hypoxia and enhanced photodynamic therapy of cancers. ACS Applied Materials & Interfaces 2019, 11 (8):7731–7742.

[13]  Yuxin Zhang, Jie Zhou, Shengnan Ma, Yiyan He*, Jun Yang, Zhongwei Gu*. A reactive oxygen species (ROS)-degradable polymeric nanoplatform for hypoxia-targeted gene delivery: unpacking DNA and reducing toxicity. Biomacromolecules 2019, 20(5): 1899-1913.

[14]  Jie Zhou, Aisha Roshan Mohamed Wali, Shengnan Ma, Yiyan He*, Dong Yue, James Zhenggui Tang, Zhongwei Gu*. Tailoring the supramolecular structure of guanidinylated pullulan toward enhanced genetic photodynamic therapy. Biomacromolecules 2018, 19(6):2214-2226.

[15]  Aisha Roshan Mohamed Wali#, Jie Zhou#, Shengnan Ma, Yiyan He*, Dong Yue, James Zhenggui Tang, Zhongwei Gu*. Tailoring the supramolecular structure of amphiphilic glycopolypeptide analogue toward liver targeted drug delivery systems. International Journal of Pharmaceutics 2017, 525(1): 191~202.

[16]  Yiyan He, Jie Zhou, Shengnan Ma, Yu Nie, Dong Yue, Qian Jiang, Aisha Roshan Mohamed Wali, James Zhenggui Tang, Zhongwei Gu*. Multi-responsive "turn-on" nanocarriers for efficient site-specific gene delivery in vitro and in vivo. Advanced Healthcare Materials 2016, 5(21): 2799~2812.

[17]  Shengnan Ma, Jie Zhou, Yuxin Zhang, Yiyan He*, Qian Jiang, Dong Yue, Xianghui Xu, Zhongwei Gu*. Highly stable fluorinated nanocarriers with irgd for overcoming the stability dilemma and enhancing tumor penetration in an orthotopic breast cancer. ACS Applied Materials & Interfaces 2016, 8(42): 28468~28479.

[18]  Yiyan He, Yu Nie, Gang Cheng, Li Xie, Youqing Shen, Zhongwei Gu*. Viral mimicking ternary polyplexes: a reduction-controlled hierarchical unpacking vector for gene delivery. Advanced Materials 2014, 26: 1534–1540.

[19]  Yiyan He, Yu Nie*, Li Xie, Hongmei Song, Zhongwei Gu*. p53 mediated apoptosis by reduction sensitive shielding ternary complexes based on disulfide linked PEI ternary complexes. Biomaterials 2014, 35: 1657-1666.

[20]  Yiyan He, Gang Cheng, Li Xie, Yu Nie*, Bin He, Zhongwei Gu*. Polyethyleneimine/DNA polyplexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene delivery. Biomaterials 2013, 34: 1235-1245.

授权发明专利

[1] 一种兼具抗菌性、粘附性、自愈性和高透明度的水凝胶及其制备方法与应用。专利号：ZL202210983358.5

[2] 基于金属配位物理混合制备水凝胶的方法及水凝胶。专利号：ZL202110121203.6

[3] 医用水凝胶的制备方法、水凝胶及敷料。专利号：ZL202110348693.3

[4] 甘露糖接枝高分子量透明质酸衍生物的制备方法及其在靶向和极化巨噬细胞中的应用。专利号：ZL202110119123.7

[5] 单糖功能化有机纳米软球及其制备方法。专利号：ZL202110379345.2

[6] 胶束辅助解离的多肽纳米级协同多药递送系统及其制备方法。专利号：ZL202110157021.4

[7] 可注射水凝胶及其制备方法和应用。专利号：ZL201910805738.8

[8] 可注射水凝胶及制备方法。专利号：ZL201811384151.6

[9] ROS响应的基因递送载体及其制备方法和应用。专利号：ZL201811314181.X

[10] Reduction stimulus-responsive gene delivery system and preparation and application thereof。美国专利号：US9707303B2